The polymerization of HbS upon deoxygenatio … Yes, Dr. Liem said, pointing to the importance of fitness in the general population. 0000023222 00000 n
There have been no formal studies into whether high-intensity exercise poses harm in patients with SCA, Dr. Liem noted. Five players with SCT, all black and all Division I football players, had died over a 5-year period (Br J Sports Med 2012 Apr;46[5]:325-30). 0000163612 00000 n
H��Wێ\�|��8?��l� b;���ر�y6��bHQ���SUM�9��*R4 X`�5�;T5_��?�:l����o>���E�>������7�^��g��>������1�~N[Jg�J��Հ�?��n����?�����?����d�^}�o�0�϶��(c{xq�7�������s48¾k�R9����3(�(\F�e����������w�����Ny�b�[����װ��_��?���=���d=o_�T��ƹ�.b�_>���������æ/_�b�g�e��\2vC�8|������ʴT3>k-��K��s�Z��x�s�m�ʹ��ri[�sO)���܋�S>�\�B�g8#^\��b��,V�j r鹔���]:�R�L>�T� 䲣xn-q����
����]9�Q���B���8�Ơ�kjp�U��,�q:��cu���3\��¤!υ"-~Qa�9�_�V����2i��O ��oT$s�F�"�z�8v�i�-ƻ��C !e���V���B�y��JJu�ʑ�ZD�7l���u�']�K����������9vw��;��#c
~��³8M�؈Z�B(�-�P�����a�v0`i�UD�@1�VmVG�1Mlsl�fNF�.�� j�eP��@��X�On�̰e������(�����L� I�����J\�9m7�p0���U�؉��M��[�N �̨K��0&�ѝ�tϏ��!��F����ג��L(5��L��4/*B�o��m�ؚ�%Կ��U6!��8S`N��Ea�*x
1S�ڹ�0�C\FS��!$g�Ӡ5J� \���aXTK%�+���g�iFb1P�+=�P�BԱ��\���@8�a>�%��!�U[(sNk\�l����Cq��y�e�Au�M���w,��.��ŏ���B��k���Rh~#��8�m)t. A combination of SCT, extreme exercise, heat, and genetic predisposition could produce harm by creating a “perfect storm,” he added. Dr. Liem led a study that found “children and young adults with SCA have reduced exercise capacity attributable to factors independent of anemia.” The study showed that peak VO2 was 30% lower in children and young adults with SCA, compared with controls (Physiol Rep. 2015. doi: 10.14814/phy2.12338). While the cause of exercise-related harm in SCT isn’t fully understood, Dr. Liem said, it’s possible that extreme states such as severe dehydration, acidosis, and hypoxemia may trigger sickling. startxref
Participating in regular physical activity is one of the most important things you can do for your health. 0000047741 00000 n
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You just have to be aware of the warning signs and complications of exercise-related illness, listen to … Meta-analysis finds no link between stroke and sickle cell trait. The information provided is for educational purposes only. Use of this Web site is subject to the medical disclaimer. 0000023722 00000 n
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That was the advice from Robert I. Liem, MD, a pediatric hematologist-oncologist who studies fitness. A combination of SCT, extreme exercise, heat, and genetic predisposition could produce harm by creating a “perfect storm,” he added. 0000002386 00000 n
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There are several reasons, he said, including concern that exercise could increase sickling of red blood cells and assumptions about “sedentary behavior” in SCA. A 2016 study, meanwhile, tracked more than 47,000 black soldiers in the U.S. Army and found those with SCT didn’t face a higher risk of death although they did have a “significantly higher risk” of exertional rhabdomyolysis (N Engl J Med. 2016 Aug 4; 375[5]:435-42). See our Other Publications. 0000087330 00000 n
“Instead of just focusing on potential harms, we should consider a paradigm shift, especially in sickle cell anemia,” he said. Dr. Liem reported having no relevant financial disclosures. 46 42
Should patients with SCA or SCT exercise?
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