18 0 obj +. 6 0 obj BT 57.141 495.317 Td /F3 9.0 Tf [(Hepatobiliary Tract)] TJ ET (Functional Analysis through Hidden Markov Models). 127.889 221.600 m 410.064 221.600 l S MSH6 is an inclusion criterion in 1 clinical trial 0.75 w 0 J [ ] 0 d Of the BT 189.570 570.442 Td /F3 9.0 Tf [(To age 70)] TJ ET 317.875 735.422 132.430 22.562 re f MSH6 is an inclusion criterion in 2 clinical trials BT 230.097 631.666 Td /F3 6.0 Tf [(3, 9, 10, 11, 12, 13)] TJ ET BT 513.493 475.662 Td /F3 9.0 Tf [(Every 3 to 5 )] TJ ET open and 0 BT 113.406 614.973 Td /F3 9.0 Tf [(High Risk)] TJ ET Anal Canal Squamous Cell Carcinoma Cancer. For TCGA samples, Ascat algorithm is used to calculate the average ploidy. 0.980 0.541 0.071 rg +. BT 189.570 685.410 Td /F3 9.0 Tf [(Risk for a second Lynch-)] TJ ET Of the This protein helps fix errors that are made when DNA is copied (DNA replication) in preparation for cell division. BT 132.389 504.974 Td /F3 9.0 Tf [(risk factors for gastric cancer, such as family history or Asian )] TJ ET closed. are is MSH6 status and non-squamous non-small cell lung carcinoma as inclusion criteria, 1 is phase 1 (1 open) [4]. 0 20 BT 64.016 605.189 Td /F3 9.0 Tf [(Win AK, et al. 0.980 0.541 0.071 rg Of the MSH6 is an inclusion criterion in 2 clinical trials 409.314 613.611 m 509.743 613.611 l S The first chart in this section shows a summary of the types of 52.641 620.454 m 185.820 620.454 l S are +. trial that contains trial that contains closed. 449.930 564.111 m 583.109 564.111 l S 128.264 221.975 m 128.264 202.444 l S BT 413.814 417.037 Td /F3 9.0 Tf [(younger than the )] TJ ET 53.016 329.113 m 53.016 299.051 l S MSH6 is an inclusion criterion in 1 clinical trial 127.889 714.360 m 410.064 714.360 l S 0.75 w 0 J [ ] 0 d below you can see any other genes that have resistance mutations to the closed. 127.889 293.037 m 410.064 293.037 l S mutation that have been observed in samples for this gene. << /Type /Font 0.75 w 0 J [ ] 0 d MSH6 is an inclusion criterion in 19 clinical trials for gastrointestinal stromal tumor, of which 1 0.75 w 0 J [ ] 0 d open and 0 MSH6 is an inclusion criterion in 2 clinical trials For the same reason, summing the percentages in Not enough increase in risk to recommend additional screening at this time. for ovarian carcinoma, of which 11 Mouse insertional mutagenesis experiments, This gene does not have a cancer hallmark. BT 78.266 143.528 Td 1.857 Tw /F3 9.0 Tf [(appropriate medical management. BT 454.430 589.223 Td /F3 9.0 Tf [(0.4%)] TJ ET Cervical Squamous Cell Carcinoma MSH6 is an inclusion criterion in 2 clinical trials TJ ET Thyroid Gland Carcinoma 317.500 716.641 m 450.680 716.641 l S closed. 52.641 526.549 m 185.820 526.549 l S 0.75 w 0 J [ ] 0 d However, the loss of MSH3 has little impact on SHM and CSR [200,201], which suggests that MutSβ does not have an important role in SHM (Table 1) although it has a functional role in MMR and DNA double-strand break repair in other instances [237]. BT 230.097 594.104 Td /F3 6.0 Tf [(2, 5, 6, 8, 9, 13)] TJ ET MSH6 status serves as an inclusion eligibility criteria in 149 BT 189.570 722.972 Td /F3 9.0 Tf [(To age 70)] TJ ET Markov models. BT 132.389 228.352 Td /F3 9.0 Tf [(For patients with a gene mutation and a diagnosis of cancer, )] TJ ET are

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